Skin irritation
  • SkinEthicTM RHE, EpidermTM* (OECD 439)
Eye irritation
  • BCOP (OECD 437), BCOP – LLBO
  • SkinEthicTM HCE
  • ICE (OECD 438)*, HET-CAM*
  • EpiOcularTM EIT* (draft OECD)
  • STE* (draft OECD)
Skin corrosion
  • Corrositex® (OECD 435)
  • SkinEthicTM RHE, Epiderm* (OECD 431)
Skin sensitization
  • DPRA* (OECD 442C )
  • KeratinoSens* (OECD 442D)
  • Vitosens®
Phototoxicity
  • 3T3 NRU*, EpiDerm™*

Cytotoxicity (ISO 10993)
  • Cell lines (HepG2, 3T3, …)
  • Endpoints: NR-uptake, MTT,…
Inflammation responses
  • Quantification of cytokines

Genotoxicity
  • Ames II / MPF / Penta I
  • in vitro micronucleus (OECD 487)
  • Comet in human blood cells
Embryo - & Developmental neurotoxicity
  • Zebrafish embryo & larvae (up to age of 5 days)

Genomics
  • qPCR
  • Microarrays

Nano Safety°
Endocrine disruption°

Validation studies

*Under implementation ° on request

Read across and QSAR
  • Physicochemistry: SPARC, EPI-Suite
  • OECD (Q)SAR Toolbox
  • Environment : VEGA, BIOWIN, ECOSAR, CASE Ultra, TOPKAT
  • Human endpoints: ToxTree, VEGA, TTC
Exposure modelling
  • Consumers: ConsEXPO , AISE REACT
  • Environment : EUSES
  • Workers: ECETOC-TRA, Stoffenmanager, ART, EMKG-EXPO, Riskofderm, S-Risk, EN-forc and other expert models

Risk assessment

Socio-economic analysis

Compound classification
  • DETNET expert
Algae growth inhibition test
  • Pseudokirchneriella subcapitata; OECD 201
Lemna growth inhibition test
  • Lemna major; OECD 221

Daphnia immobility test
  • Daphnia magna; OECD 202
Daphnia reproduction test
  • Daphnia magna; OECD 211

Fish acute toxicity, and prolonged toxicity test
  • Danio rerio; OECD 203 - OECD 204
Fish embryo acute toxicity test (FET)
  • Danio rerio; OECD 236
Fish, short-term toxicity test on Embryo and Sac-fry stages
  • Danio rerio; OECD 212

Worm mortality test
  • Eisenia fetida; OECD 207
Worm reproduction test
  • Eisenia fetida; OECD 222

Plant growth inhibition test
  • different species; OECD 208

Biodegradation tests
  • OECD 301 B/D - OECD 302

HOW CAN WE HELP?

Our multi-disciplinary teams have the expertise to accomplish all your toxicology and regulatory needs

Data collection, compound analysis, fill the gaps (QSAR’s or read across), testing services (ecotoxicity, biodegradation studies, in vitro human toxicity), validation studies, exposure scenarios, safety analysis, second opinion, full dossier preparation and follow up,…

GLP certified - EU-NETVAL registered lab

REACH / CLP /…

Have no secrets to us !

TESTING SERVICES

We perform!

MEDICAL DEVICES

We take care of biocompatibility!

LABEL

We apply

VALIDATION STUDIES

We are your partner!

SAFETY BY DESIGN

We support the future!

ENVIRONMENT HEALTH SAFETY
health@vito.be


VITO N.V.
Boeretang 200 | 2400 MOL | BELGIUM
Tel. + 32 14 33 55 11
www.vito.be